2024 · 2h 21m · R
Have you ever dreamt of a better version of yourself?
A fading celebrity takes a black-market drug: a cell-replicating substance that helps her create a younger, better version of herself.
Have you ever dreamed of a better version of yourself? You. Only better in every way. Seriously. You've got to try this new product. It's called the Substance. It changed my life. It generates another you. A new, younger, more beautiful, more perfect you. And there's only one rule: you share time. One week for you. One week for the new you. Seven days each. A perfect balance. Easy, right? If you respect the balance...what could possibly go wrong?
Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
Edward Hamilton-Clark
Fred
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jiselle Henderkott
Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
TV Host
Vincent Colombe
Man in Suit #1 - Harvey's Office
Jordan Ford Silver
Assistant Director - Pump It Up Show
Oscar Salem
2nd Assistant Director - Pump It Up Show
Matthew Luret
Floor Runner
Jana Bittnerová
Maria
Olivier Raynal
Alan - 2nd Agent
Tiffany Hofstetter
Stylist
Nicolas Royer
Guy in the Elevator
Nathan Rippy
Assistant Director - New Year's Eve Show
Virginie Kotlinski
Mother - New Year's Eve Show
Brett Gillen
Director of Photography - New Year's Eve Show
Aurélien Lorgnier
Screaming Man
Ivan Sellier
Screaming Man
Philip Schurer
Screaming Man
Christian Bourmier
Shareholder
Martin Graham
Shareholder
Christian Bordeleau
Shareholder
Patrick Hamel
Shareholder
Bryan Jones
Greeting Person
Adam Carage
Happy Birthday Person
Maria McClurg
Happy Birthday Person
Andrew Desmond
Happy Birthday Person
Laura Puech
Isabella
Cécile Vogt
Elisabeth (Young) - Walk of Fame / Pump It Up Show Dancer
Jean Miel
Worker Walk of Fame
Barthelemy Thomas
Billboard Technician
Ashley Lambert
Additional Voices (voice)
Ranjani Brow
Additional Voices (voice)
Chase Fein
Additional Voices (voice)
Shane Sweet
Additional Voices (voice)
William Calvert
Additional Voices (voice)
Michael Corbett
Additional Voices (voice)
Stephen Apostolina
Additional Voices (voice)
Yann Bean
The Substance (voice)
Audjyan Alcide
Pump It Up Show Dancer
Laura Boera
Sparkle Your Life Show Dancer
Sophie Mercier
Sparkle Your Life Show Dancer
Aleksandra Kedzierska Fontaine
New Year's Eve Show Dancer
Lola Donati
New Year's Eve Show Dancer
Kate Matthews
New Year's Eve Show Dancer
Pauline Richard
New Year's Eve Show Dancer
Daria Panchenko
New Year's Eve Show Dancer
Matthew Géczy
Bob Haswell (uncredited)
Namory Bakayoko
Silhouette (uncredited)
Gregory Defleur
Happy Birthday Person (uncredited)
Coralie Fargeat
(uncredited)