| 2023 | Spider-Man: Across the Spider-Verse | Doc Ock (voice) | 8.50 |
| 2018 | Spider-Man: Into the Spider-Verse | Doc Ock (voice) | 8.40 |
| 2016 | The Do-Over | Becca | 5.70 |
| 2015 | The Visit | Mom | 6.30 |
| 2013 | The Secret Life of Walter Mitty | Odessa Mitty | 7.30 |
| 2013 | We're the Millers | Edie Fitzgerald | 7.00 |
| 2012 | The Dictator | Pregnant Woman | 6.50 |
| 2008 | Step Brothers | Alice | 6.90 |
| 2006 | The Holiday | Bristol | 7.00 |