| 2026 | Spider-Man: Brand New Day | May Parker | 8.10 |
| 2024 | Brothers | Bethesda Waingro | 5.40 |
| 2021 | Spider-Man: No Way Home | May Parker | 8.10 |
| 2018 | The First Purge | Dr. May Updale / Architect | 5.20 |
| 2017 | Spider-Man: Homecoming | May Parker | 7.40 |
| 2016 | Captain America: Civil War | May Parker | 7.80 |
| 2012 | Parental Guidance | Alice Simmons | 6.00 |
| 2011 | Crazy, Stupid, Love. | Kate | 7.40 |
| 2011 | The Lincoln Lawyer | Maggie McPherson | 7.30 |
| 2010 | Cyrus | Molly Fawcett | 6.30 |
| 2007 | Before the Devil Knows You're Dead | Gina Hanson | 7.30 |
| 2007 | Wild Hogs | Maggie | 5.90 |
| 2003 | Anger Management | Linda | 6.30 |
| 2000 | The Watcher | Dr. Polly Beilman | 5.30 |
| 1989 | Seinfeld tvSeries | Marisa Tomei (2 eps) | 8.90 |